Surgery to prevent breast cancer requires a patient-doctor dialogue about risks, benefits

Risk-reducing mastectomy saves lives of women who, because of hereditary or other risk factors, may have a very high lifetime risk of developing breast cancer, according to two new journal articles written to guide physicians and patients. All of these women should also discuss with their physicians nonsurgical options such as screening and medications to …

Study reveals the gateway to conscious awareness

During our waking hours, the brain is receiving a near-constant influx of sensory signals of various strengths. For decades, scientists have wondered why some signals rise to the light of conscious awareness while other signals of a similar strength remain in the dark shadows of unconsciousness. What controls the gate that separates the shadows and …

Using 4D printing to enable vascularization, bone tissue regeneration, spinal fusion

Spinal fusion is frequently performed to restore spinal stability in patients with spinal diseases, such as spinal stenosis, vertebral fractures, progressive deformities, and instability. In the past two decades, there has been marked increase in the number of people over 65 years in age who have needed spinal fusion surgery.

When drug manufacturers raise the list price for prescription drugs, do patients’ out-of-pocket costs rise too?

When drug manufacturers raise the list price for brand-name prescription drugs, do patients’ out-of-pocket costs rise too? A new study published in JAMA Network Open by Dr. Benjamin Rome and colleagues in the Brigham’s Division of Pharmacoepidemiology and Pharmacoeconomics finds that more than half of patients may experience increases in out-of-pocket spending when drug prices …

Scientists find gene mutation linked to exfoliation syndrome, most common cause of glaucoma

A team of researchers from the Agency for Science, Technology and Research’s (A*STAR) Genome Institute of Singapore (GIS) and Bioprocessing Technology Institute (BTI), as well as Singapore Eye Research Institute (SERI), have identified a genetic mutation (functionally defective CYP39A1 gene) associated with exfoliation syndrome, the most common cause of glaucoma. The findings could pave the …