Researchers identify cause and drug targets for bewildering rare children’s disease

Researchers have finally cracked the code of a bewildering pediatric disease that sets off a characteristic cytokine storm—a harmful immune system overaction resembling one that arises in COVID-19 cases—and can lead to catastrophic multisystem organ failure or neurodegeneration. Their study, which identifies the cause of the cytokine storm and possible treatments, was published in Nature …

Discovery of genetic drivers linked to progression in Parkinson’s disease

A key driver of patients’ well-being and clinical trials for Parkinson’s disease (PD) is the course the disease takes over time. However, nearly all that is known about the genetics of PD is related to susceptibility—a person’s risk for developing the disease in the future. A new study by investigators from Brigham and Women’s Hospital …

Trial demonstrates early AI-guided detection of heart disease in routine practice

Heart disease can take a number of forms, but some types of heart disease, such as asymptomatic low ejection fraction, can be hard to recognize, especially in the early stages when treatment would be most effective. The ECG AI-Guided Screening for Low Ejection Fraction, or EAGLE, trial set out to determine whether an artificial intelligence …