Mechanisms of kidney protection by gliflozins

SGLT2 inhibitors (gliflozins) were developed as oral antidiabetics. They enhance urinary glucose excretion by inhibiting SGLT-2 (sodium-dependent glucose co-transporter-2) in the renal tubuli. The discovery of kidney benefits beyond the lowering of blood sugar has been made by Professor Christoph Wanner from Germany: The EMPA-REG OUTCOME study initially showed that the rate of cardiovascular events …

In controversial decision, FDA approves first new Alzheimer’s disease drug in nearly 20 years

The US Food and Drug Administration on Monday approved the use of the experimental drug aducanumab for early phases of Alzheimer’s disease — despite an FDA advisory committee concluding last year that there is not enough evidence to support the effectiveness of the treatment.

Dapagliflozin provides kidney protection even in cases of FSGS kidney disease

Focal segmental glomerulosclerosis (FSGS) is a rare form of kidney inflammation (glomerulonephritis) in which the glomeruli become increasingly scarred (sclerotic), leading to progressive loss of kidney function. Dysregulation of the immune system plays a role in pathogenesis, which is why immunosuppressive therapy with glucocorticoids can be successful, alongside supportive therapy (especially blocking of the renin-angiotensin …

Cheney: Trump inciting January 6 riot ‘the most dangerous thing’ a president has done

Wyoming Republican Rep. Liz Cheney accused former President Donald Trump of having committed the worst violation of a president’s oath of office by inciting the January 6 Capitol insurrection — and taking a jab at House Minority Leader Kevin McCarthy over his subsequent visit to Trump at Mar-a-Lago.