Popular sepsis prediction tool less accurate than claimed

One in three patients who dies in a hospital has sepsis, a severe inflammatory response to an infection, marked by organ dysfunction, according to the Centers for Disease Control and Prevention. This heavy toll makes predicting which patients are at risk for developing the devastating condition a top priority for clinicians.

Investigational Alzheimer’s drug improves biomarkers of the disease

An investigational Alzheimer’s drug reduced molecular markers of disease and curbed neurodegeneration in the brain, without demonstrating evidence of cognitive benefit, in a phase 2/3 clinical trial led by researchers at Washington University School of Medicine in St. Louis through its Dominantly Inherited Alzheimer Network-Trials Unit (DIAN-TU). These results led the trial leaders to offer …

Protein linked to heart health, disease a potential therapeutic target for dementia

By the time people with Alzheimer’s disease start exhibiting difficulty remembering and thinking, the disease has been developing in their brains for two decades or more, and their brain tissue already has sustained damage. As the disease progresses, the damage accumulates, and their symptoms worsen.