A team of researchers affiliated with multiple institutions in the U.S. has found that reciprocal repulsions of cell-surface molecules prevent tangling in parallel hippocampal networks. In their paper published in the journal Science, the group describes how they used single-cell RNA sequencing to profile developing cells in the hippocampus and what they learned by doing so. Yajun Xie and Corey Harwell with Harvard Medical School have published a News & Views piece in the journal Nature outlining the work done by the researchers on this new effort.