Death rates from chronic conditions like lung disease and cardiovascular disease and so-called “diseases of despair” such as opioid overdoses are known to be higher in rural areas than in large cities, with differing economic, social and political circumstances influencing people’s access to care. To examine disparities in mortality rates for all causes of death, researchers from Brigham and Women’s Hospital used a Centers for Disease Control and Prevention (CDC) database to analyze all deaths occurring in the U.S. between 1999 and 2019. They found that age-adjusted mortality rates (AAMRs) declined in both rural and urban populations, but that the gap between the death rates dramatically widened as white individuals aged 25 to 64 in rural areas faced increasing AAMRs. The research findings are published in JAMA.