Editor’s note: The Centers for Disease Control and Prevention and the Food and Drug Administration lifted the pause on the Johnson & Johnson COVID-19 vaccine on April 23, 2021, but the labels and fact sheets given to patients will carry a warning about the exceedingly low risk of developing blood clots. Also, close monitoring of the J&J vaccine along with the Moderna and Pfizer vaccines that were given emergency use authorization will continue. Dr. William Petri, an infectious-disease physician and immunologist at the University of Virginia School of Medicine, explains this development and why the agencies decided that the benefits of the vaccine far outweigh the risks.