Two studies related to percutaneous coronary intervention (PCI) evaluating the use of risk-avoidance strategies and robotic-assisted technology, respectively, are being presented as late-breaking clinical science at the Society for Cardiovascular Angiography & Interventions (SCAI) 2021 Scientific Sessions. An analysis of strategically avoiding high-risk PCI cases indicates systematic risk-avoidance does not improve, and may worsen, the quality of hospital PCI programs. A study of a robotic-assisted PCI shows the technology is safe and effective for the treatment of both simple and complex lesions; this has the potential to address the occupational hazards associated with radiation exposure and procedure-related orthopedic injuries for physicians.