Study of severe COVID-19 helps uncover the roots of sepsis

Sepsis is a dreaded, life-threatening condition that can occur when an infection spins out of control. Like a tsunami after an earthquake, sepsis occurs when an infection triggers a dysregulation of the immune system, which leads to widespread organ damage and even death. The condition can result from nearly any kind of infection and afflicts …

DNA methylation changes in neurons of bipolar disorder patients

A research collaboration based in Kumamoto University, Japan, has revealed the DNA methylation status of gene transcriptional regulatory regions in the frontal lobes of patients with bipolar disorder (BD). The regions with altered DNA methylation status were significantly enriched in genomic regions which were reported to be genetically related to BD. These findings are expected …

Brain connections mean some people lack visual imagery

New research has revealed that people with the ability to visualize vividly have a stronger connection between their visual network and the regions of the brain linked to decision-making. The study also sheds light on memory and personality differences between those with strong visual imagery and those who cannot hold a picture in their mind’s …

Structure of enzyme that causes Parkinson’s promises pathways to new drugs

Structural biologists at St. Jude Children’s Research Hospital have determined the detailed structure of an enzyme whose mutated forms are known to cause Parkinson’s disease. The achievement opens a research pathway to develop new drugs that can specifically target the aberrant form of a protein enzyme called LRRK2.

Many adults with cardiovascular disease know the risks, yet still don’t stop smoking

Many adults with a history of cardiovascular disease (CVD) continue to smoke cigarettes and/or use other tobacco products, despite knowing it increases their risk of having another cardiovascular event, according to new research published today in the Journal of the American Heart Association.