Nrf2: The custodian regulating oxidative stress and immunity against acrylamide toxicity

Acrylamide is a toxic chemical compound that affects the nervous system. It is widely used in industries such as paper production, plastics, and wastewater management, and is also a byproduct of commonl-used food processing methods, which makes human exposure to acrylamide inevitable. Therefore, many studies have focused on understanding the toxic effects of acrylamide and our body’s response to them. Generally, in response to toxicity, the body’s cells release protective factors and antioxidants to remedy the damage. This response is activated by various cellular machinery. One such activator is a protein called ‘nuclear factor erythroid 2-related factor 2’ (Nrf2), which is a master regulator of the response to oxidative stress and the immune system.

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